I have Leupold CDS scopes, target turret scopes and ballistic reticle scopes. Honestly, I have never used any of the "toys" when hunting. (Always 500 yards or less)
I quick guess the range, based on previously ranged landmarks, hold over, and/or off for the wind and shoot. Afterwards, every time I think, hmmm I guess I could have looked at the reticle, or dialed the scope. In the moment I never think of it, just make the shot, go gather up your kill. Taking the time to mess with the toys may cost you the shot opportunity.
That's my experience.
Edit,
Look at ballistic charts for most hunting cartridges. Zero'd at 200 yards, hold 6-8" over for 300, 18" over for 400 and 40" at 500 yards. Most hunting cartridges will make a kill shot on deer sized game (or larger) with the same values. (check your cartridge for sure, but generally with the exception of 500 and out, the numbers will put you in the chest of a deer)