So now we aren't mathing our quarry to death...but the dang things somehow die so we have to figure out a mathematical explanation for it?
How about this: When a hole is created in the animal's body, it will suffer damage to internal structures and lose blood. The bigger the hole, the more damage. The deeper the hole, the more damage, up till the point where the hole goes all the way through. And the faster the object creating the hole moves through the body, and the more it expands and deforms on its journey through the body, the more damage and blood loss.
Did momentum kill the critter? Well, momentum is the tendency of a body...in this case, a projectile...to remain in motion. Moving through the body of an animal exerts a lot of friction on the proectile, and forces it to cut or punch through a great deal of tissue, bone, etc. All of this acts to slow down and stop the projectile. If the projectile possesses sufficient momentum, it will overcome this opposing force and continue on further through the body. If it possesses insufficient momentum, it will come to a stop before penetrating nearly as far. That heavy, high-momentum .45-70 bullet just plows through with momentum to spare; the expanded lightweight .243 bullet, with little momentum, can't begin to match that performance.
A deer standing broadside? No problem; the .243 is perfectly capable of complete penetration, and so the fanboys go "OOOH! Look at that! My .243 kills just as fast as the big gun! Quick, let's math the crap out of this phenomenon!"
But, again, things aren't always so perfect. The deer is standing square facing the hunter, or maybe very slightly quartering toward...or perhaps it's quartering away from a hunter on day 7 of his one-week hunt. Complete penetration on this shot...the only one he "has"...requires the bullet to traverse four feet or more of bone and tissue. That .45-70 still just keeps on trucking and sails off into the sunset...but the 80- or 100gr .243 opens up into a flat coin trying to push its big flat insubstantial face through the animal in the most difficult way possible...and it fails miserably. Maybe it will manage to go deep enough to cause enough damage that the critter is killed...maybe on the quartering-to shot...but there's a more-than-decent chance that it won't, especially on the quartering-away shot or one that hits big bone. In this case, the .243 simply isn't even adequate for deer...but then we will probably hear that the guy didn't "do his part" correctly. That's true, he didn't. He picked a cartridge that had inherent limitations, and then he attempted to exceed those limitations.
But that's an exaggeration; a .243 isn't going to expand to .50-caliber. It will expand some, it will penetrate some more, but its lack of weight and also frontal area won't let it match a larger cartridge that starts out bigger, weighs more and also expands to a similar degree.
So use a .243, and limit yourself to .243-capable shot presentations. Or, do your part and choose a gun that will allow you to capitalize on all ethical shot presentations. You won't even need a calculator.