My experience with buffalo is that if you don't hit them hard in the head, neck, spine, shoulder, they won't go down quickly...Hi velocity bullets that don't hit these areas will just zip through and the buffalo will keep doing what buffalo do.I prefer a much bigger cal. with heavier bullets and shots that hit major bone/skeletal areas. If you chose to avoid hitting a buffalo in those parts I would suggest you study up on the buffalo anatomy as the vital heart area is forward and lower in the body then one would think, it may seem this way because of the big hump/front shoulder.