^ Right off the top, I am biased. I love the .416Rem. Gotta state that clearly.
Ganyana is biased against it, which is just a differing opinion. It's not right or wrong. You generally find that once a person has formed an opinion, they pretty much never budge from it, but will forever echo their opinion, even though they may have told everybody 1,000 times.
Like I bet you know TBart's opinion on the TSX already...
Fact: When INTELLIGENTLY loaded, there's no issue with the .416Rem. It's also a fact that a helluva lot of shooters will overload cartridges. Reference any online reloading data and you find that out.
There are modern powders that are not heat sensitive. RL-15 is one and it's one of the best powders available for the .416Rem.
I load mine to a sedate 2350fps at the muzzle, but had no trouble making a 250 yard shot with that.
* And yes, I am aware of Ganyana's credentials and I really have none...