Seriously?
You're saying that my 300WinMag using 180 gr. Nosler Part. will be outperformed by my 25-06 with 100 gr. TSX? I have actually shot elk with both bullets and caliber combos, and the 300 puts them down faster. Real world experience, not paper data.
Some calibers aslo just perform better, no matter what the numbers say. My 9.3x62 ,for example, seems to have incredible knockdown power and effect on large animals, even though the numbers on paper aren't overly "impressive".
I would always suggest to pick heavy, large diameter bullets over light, fast ones for bigger game like elk and moose. Many hunters seem to be obsessed with lightning speed and flat trajectory, sacrificing bullet weight and energy.
I've taken 2 bull elk so far, using a 300 WM. Granted, not a lot of basis for conclusions, but...
First one with Federal 200 gr Sierra Gamekings at about 50 yds, rated at about 2900 fps. Through the lungs. Didn't even flinch. Stood there for about 20 seconds, during which I put a second shot in its neck, to which it also didn't visibly react. Then it finally fell over and quickly died.
Second one with Federal 130 Barnes TTSX at about 100 yds, rated at 3500 fps. Through top of shoulder and both lungs about 6" below the spine. Lurched real hard, ran about 30 yds and dropped dead. Damage to the lungs was absolute!
The advantages of the 130 TTSX are...
1) Superior construction, virtually no weight loss...save for the odd petal that might break off.
2) Considerably flatter shooting out to 300 - 350 yds.
3) Considerably less recoil from my Vanguard 300 WM, which definitely takes the edge off of going a dozen or so practice rounds at the range.
Personally, I'm no longer a believer in heavy for caliber bullets, given the quality of ammo now available. A number of articles I've read in the last couple years, notably regarding lightweight Barnes bullets at relatively hyper-velocities, have convinced me that bullet construction, accuracy, and shot placement are much more important than ft lbs/sq in.
And, if I'm going to consider 300 - 350 yd shots now and again, then a flat shooting bullet that still has lots of whack left when it arrives on target, and gets there accurately, has its merits.