Its kind of an open ended question. Some stuff i load for, some stuff i don't. I have dies for a dozen or so calibers, but only seriously load for 2 or 3. Several rifles that I use for bush hunting are milsurp and/or iron sights, which will never drive nails without being scoped. I have an old model 70 carbine 30.06 that just LOVES cheap 180gr power points, so i don't load for it. I tend to only load for ammo that I cannot get, can improve accuracy over factory/commercial ammo, or greatly improve the cost of shooting. And yet further considerations that have not been mentioned in the OP, stuff like 30-30 and 7.62x39 soft points are cheap and offer good enough accuracy for their intended purpose that there is no point trying to improve them. Time for reloading is also valuable, not just components. I spend my time loading only where it does make a noticeable difference.