I have both calibers. The ballistics are very similar. pdg300 is right on with his comments about the 204 Ruger, but I would add that you can rely on it well past 200 yd. Do a search on the Predator Masters forum, and you will find reliable accounts of kills on coyotes out to nearly 400 yd. The 22-250 is an equally good performer, and comes with many more suitable factory ammunition offerings at the cost of more noise, recoil and a shorter barrel life. If your friend is not a reloader, go with the 22-250. Otherwise, he can't really go wrong with either caliber, and I have to say a 204 is lotsa fun.