+1 for the .204.
But, a better solution: I have both
I much prefer the 204 on the balance:
-
slightly BETTER range and downrange numbers, due to the higher BC of it's 40-grainers. Check the numbers.
www.6mmbr.com has a 20-cal page.
-Wind resistance is also slightly better, due to a more efficient bullet (higher BC)
-less recoil. Although the 22-250 has minimal recoil, the 204 is noticably less, allowing for faster re-acquisition, and easier to spot your shots
-more shots between 'cool-down.' This is the big one for me. I hate waiting for the gun to cool down. I get twice as many shots between cool-down on my .204
-Better barrel life (or so they say)
-Cheaper to reload - less powder. ~25-ish grains for the 204, 35-ish for the '250
This is balanced against its disadvantages:
-harder to find components for (for now...)
-only explosive, frangible varmint bullets available (heh, that's what I'm after though

-need new cleaning rod & accessories
-uncertain future, depending on popularity (looking good though. On Ammoguide.com's 'most frequently viewed' list, it's just after the '06!)