As I'm sure you know its very hard to get a hollow point to expand at subsonic velocity. I doubt any of the .22 subsonic stuff expands much.
When I said "hit hard" I was referring to the penetration and greater energy inherent in the heavy bullet. I realize that's wasted if it passes through an object the size of say a gopher, but if you wanted to use it against a larger target I feel it would be superior to either .22 short or some of the lighter .22LR subsonic loads.
However I would defer to your knowledge in this area Suputin (which I'm told is extensive), feel free to edjoomakate me if I'm wrong.