Well, sort of. A lot of the single shot 22's are casual enough in fit, and 22 LR is low enough in pressure that you can get away with things you would never try in a centerfire. I've seen bolts swapped around in Cooeys quite a few times with no ill effects. Just be cautious the first time you shoot it and inspect the brass closely to see what is going on in the chamber. FWIW - dan