Aww, I've used 100 gr moly coated X bullets and dropped big moose bulls easily, (at least no more than a 5 second delay before they dropped on their face) . I am fully confident in my .25-06, and it often gets the nod when I hunt multi-species in the same hunt. Whizzing along frozen lakes to find wolves, often , a moose will be seen 300-600 yds close to a shoreline. I've taken two moose bulls at 300 & 360ish yards from my skidoo seat with a 100 gr x and never thought twice about it. A Good scope helps when you use the marginal sized calibers though. I once had to shoot a cow moose with a .243 win, and she went down in short order on a return home 2 week visit to Nfld. (I had to borrow the gun)
I always take a bigger gun if I am hunting moose only, but I have no qualms about the hot quarterbore, if you are within your abilities when you pull the trigger. (I personally limit my own shots to no more than 400 with anything , and thats on a wide open lake)
Hunt within your skill level.