For solely Yotes I would try a 75gr Vmax
and powders like H4350, H4831 and RL19
You can push a 75gr pill out of a .25-06 between 3500-3700fps that would be a hammer on yotes and very flat shooting...
If you plan on hunting bigger game with it I recommend developing a load around a specific bullet weight to cover both so you don't have to re-zero with each new load......(example) I am working on a .264wm I will be using 129gr SST's for load development(cheap), plinking and varmints I will be switching over to 129gr Interbond's for medium size game...For the .25-06 I would look at the 100gr Nosler BT for varmints and fun then the 100gr Banes TSX for medium game....Those worked well in my .257wby.
If you need a box of 100gr .257 TSX's PM me got some for sale.