Bruno, use your hunting loads for the gophers. Then you will learn how to dope wind, and how much holdover is needed at various ranges. I don't know if you have a laser rangefinder or not, and if not, it is an excellent investment.Thousands of gophers have been dispatched to the promised land with 140 grain boattails out of my 270 weatherby magnums. Many 100's of them have found how effective a 200 grain out of a 300 Winmag is as well. I can't count high enough tototal the number that have fallen to 100 and 120 grainers out of the 25 06.When you can consistantly connect on a gopher with your hunting load at 400 yards, a deer is like shooting a barn. The old adage, "BEWARE THE ONE RIFLE HUNTER!" has merit. He knows that where he points it, is where it is going. Years ago, I experimented around with the light bullets,and the fast stepping varmint rounds and applied them, with great effect to the yotes and other vermin, but I get much more satisfaction out of the "heavies" shooting the bullets that they were meant for, and taking the loooooong shots. The satisfaction is unbelievable when you blast a mighty gopher at 300 yards with a 375 H&H 300 grain H- frame and make a one shot kill.