I am shooting 73 grains of reloader 22 behind 165 grain Barnes X bullet. Winchester large rifle magnum, and Winchester brass. My other load that I will be using hunting is 75 grains Reloader 19 behind a 180 accubond bullet. Same brass/primers. Both have been accurate at the range, and I care more about accuracy than velocity. (I have only chrono'd the X bullet and it is reaching 3040 fps 15 feet from the muzzle. Thats plenty fast for me, I am only shooting at 250 yards or less MAX. But the guys ahead of me are right, use a slower powder for 300 win mag. H1000 is a powder I will try next as tons of people say its great in the win mag. Good luck