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Use a safe starting load for H4350, and start off with your IMR4350, work up in 1/2grain increments, establish accuracy first, 100fps is'nt gonna matter in any practical field application.
Of course watch for the usual signs of high pressure.
I've used the IMR 4350 in my .300WSM with good results for 180 bullets. My best results with the 168 gr TSX has been with RL 15. I have a Barnes page here I got somwhere on the web that I'll PM to you if I can attached it? Shows loads for 165 TSX with IMR 4350...
Velocity and pressure readings represent average values
obtained under controlled conditions. The values shown may vary substantially with the components and the reloading techniques employed. We suggest the charge weights shown be reduced initally by 10% to compensate for possible variations from the published data. The loads may then be increased as pressure indications permit.
I use the IMR 4350 in my T3 300 WSM. I got pretty good groups (less than 1") with 67.5 grains. I used the load data from Barnes reloading book for the 165 grain XBT. Their book recommends to start at 61.0 to a max of 66.0. But the TSX has a lower pressure. Speed for the load averaged 3020 fps.
Imr 4350 165 grn tsx starting load: 61.0grn = 2889 fps
max load: 68.0grn = 3148 fps with a load density of 105%
if you work up your loads you can probably get more fps and load a bit hotter
if its accurate