Hi, Some notes of personal use of 40 S&W before moving to Canada. I have been told that we are not allowed to prepare for home defence here in Canada, so I shall not comment on that for Canadian application.
I culled baboons on the campus where I worked. Carried a concealed Glock 23 in summer, a concealed Glock 35 in winter. Carry ammo was 165gr Hornady HydraShok and later 165gr Speer Gold Dot. Baboons shot at ranges averagign possibly 10-12 yards, longest shot 35 yards. ALL shots had full penetration, front to back, or sideways throught the shoulders, and showed full expansion, and once had a shot penetrate 2" pine beam behind the baboon and into a brick wall. Most baboons would still move around for a few seconds after a solid hit in the torso, even through the heart; usually no Hollywood style instant death.
I shot (euthanased) one small antelope (about 12kg) that had been hit by a vehicle and had both front legs broken. Shot it sideways through both shoulders at about 12 yards (165gr Speer Gold Dot) and the bullet went flying away behind the poor little guy. I carried 180 gr Eldorado Starfire in my G23 as back-up while bushpig hunting with a rifle at night.
The CorBon 135gr in 40 S&W might give best stopping power factor with least over penetration. Accuracy slightly wider than Speer Dold Dot. My son in the South African police believed in the 135gr CorBon for off duty carry before upgrading to 45 ACP.
I was told that the Toronto police use 180gr Winchester Ranger HP, as sold by Wolverine. Works well in my Glocks.