1. How much will substituting a Federal primer rather than a Winchester primer affect the safety of my loads?
If you're not on the raggety assed edge of the load data, probably won't. If you want to load right up to the maximum published loads, I wouldn't do it in my 40 S&W reloading.
The .40 S&W is not in the tops where auto pistol loads are concerned regarding pressures, but it is up there. With regard to that and a few other firearm related issues, the .40 S&W is one round where it is my personal opinion that swapping around components and load data when loading max loads is a very poor idea. Mind you, I am probably more prudent than many reloaders. I haven't had any bad experiences in reloading handgun for just under 40 years, most of that on progressive presses, so I'm pretty comfortable with this approach.
I'm not big on loading anything to the thin edge of maximum published data anyways. My personal opinion is there is probably minimum benefit for the degree of reduction in the fudge safety factor and the extra stress on the firearm. But, if and when people decide to go there, I think the closer you religiously adhere to the published load specifications as you approach maximum loads, the better off you are.
2. Can I use a load where the bullet weights are the same but the brand or nose/kind are different? For example on page 342 of my Lyman 48th Ed. Reloading Handbook they list a recipe for 180 gr. Jacketed HP. Is it correct to assume you could substitute non HP bullets?
The answer is "it depends". If you seat a longer bullet of the same weight to the same depth as specified for a shorter bullet of the same weight, you have just reduced the internal capacity of the case - and in the stubby little .40 S&W, that reduction can be significant. Then there's all the little details of whether you're comparing lead bullets to jacketed, etc.
For middle of the road loads and small differences between bullets, I would be prudent but wouldn't be too concerned about differences.
I don't intend to make it sound like you're playing with dynamite. Perhaps a better way is to suggest the .40 S%W deserves a little extra respect when deviating from published data, and the hotter you intend to load then the more respect you need to show.
3. I was disappointed to see that my Titegroup wasn't listed there so I checked the Hodgdon site and found 180 gr. Hornady XTP listed for Titegroup. They list 1.125" for the OAL. How close can I approach this? If I can adjust my seating die to 1.120" is that ok? I plan to experiment a bit to see how accurate varying lengths are and how consistently they load.
The load they list is just 1700 psi below the SAAMI maximum. Going over the maximum won't initiate instant Armaggedon, but I think most would agree that staying below the SAAMI max - especially if you're going to go through the number of rounds a competitor does - is a good idea.
Both are jacketed bullets. I would calculate the difference between the length of the HP given in the load data and the bullet you intend to use. I would not seat the substitute bullet any further into the case than the base of the bullet in the load data would go. By doing this, you are ensuring that the internal case capacity that published load is operating at is not reduced and, if anything, increased.
On a general note, if you cannot find a published load that matches the components you have on mind, I would consider using the Titegroup and primers as "shooters" in slightly detuned loads for practice. I don't think Titegroup is optimal in the .40 S&W anyways, particularly in a reloading setup that does not have a powder checker die in it. I suspect you could get a double charge with some of those Titegroup loads, whereas you can't double charge with Longshot or Blue Dot for example. And with those loads, you can get the velocities with your bullet that Titegroup will produce, with significantly lower pressures.
The good news about the .40 S&W is that there is LOTS of published and tested load data out there to choose from that uses commonly available components.
I guess my final point is I do a lot of loading for .40 S&W and have loaded everything from the 135 gr. HP's to the 200 gr. heavy hitters. The .40 is actually relatively easy to load for, but thoughtful selection of loads and powder choices can really improve the results.