Just noticed your other thread, re 45-70. I know full well my Marlin 1895 would make 1 moa at 100 yards, if I can aim and hold it just a hair better.
Using 420 grain cast bullets, I have made a 5 shot group of 1.2'', but other than one "flyer," four of them made .9 inch. This was made with a very light load of 4227 powder with backing to hold the powder in place.
With a fairly heavy load with 420 grain bullets, 45 grains of IMR 4895, I have made a ten shot group of just over 1½ inches.
I'm told on good authority that 3031 is the magic powder for the 45-70, but so far, I don't have any of it.
In the original copy of the Lyman handbook of Cast Bullets, they show eight different powders for loading 325 grain gascheck bullets in the 45-70. These vary from Unique, (as low as 10 grains) to 4320, as high as 52 grains.
If I was going for accuracy with 300 grain bullets, I would certainly use the faster powders. There is a real good chance that Unique might give you what you want.
If you are wondering about the bullets touching the rifling, there is no better way of getting consistant release pressure of the bullet. If you can make them touch, I certainly would.