Did the ammo come that way or where the bullets pushed in because of the tube mag on the Ranch Hand?
If they are loaded to the old black powder pressures (as most factory ammo is) and are being fired in a modern firearm it is unlikely it will cause a catastrophic failure but it could still happen. The ranch hand action in 45 Colt is the same as for 44 mag which can obviously handle the 44 mag pressure. The 45 Colt is 16,000 CUP which is somewhere around 17,000psi and the 44 mag is 36,000psi. Will the bullet being that far into the case cause it to spike above 36,000 psi? Possibly. Would I risk it personally? No.
I'd put them aside and wait until you start reloading (which is inevitable with 45 Colt unless you are made of money) and just pull them with a bullet puller. Toss the powder, melt down the bullet if you get into casting, and reuse the brass and primer.