After seeing how well a S&W 500 shot that a buddy of mine had just acquired, I decided I needed one. A short while later, I acquired an 8 3/8".
After the first initial amount of heavy loads, I found that even with the rubber Hogue grips it came with, there was a fairly intense pain felt on the inside of the knuckle of the index finger. I had an old set of Jordan Trooper stocks by Herritt's for the N-frame S&W that I modified to try and minimize that recoil effect and it worked. With full house loads, it's still a 'handful' capable of inflicting pain at both ends,

but now manageable

.
With the 500, more than any other handgun calibre handgun I've ever had and reloaded for, anything I 'feed' it seems to show super accuracy. Hot loads, light loads, heavy bullets, light bullets, cast or jacketed, they all shoot well. I did notice though, with bullets over 500grs, the groups started to open up.
I don't have a 460,

yet but do plan on eventually acquiring one. While it seems the flexibility it has of being able to handle a couple of other additional calibres is a draw for some, myself, I'd rather just accomplish the same by shooting lighter loads with/in the 460 cases. However, that's just me but it does give me the excuse to 'acquire' additional handguns

.