A hot load on a plain base bullet can easily result in tumbling. The theory is that it erodes the unprotected base of the bullet, and as it leaves the barrel, a jet of hot gas releases from one side, resulting in a tumble, or yaw, in the bullet in flight.
Hot loads with plain base bullets can lead your barrel to the extent the rifling begins to disappear in as little as fifty rounds. That I've seen first hand.
Try a lighter load, and see if the accuracy improves.