In my opinion, if you are shooting under 600 or so yards, you simply go with the bullet that has the best accuracy/groups at 100 or 200 on paper while you are doing load work ups, in your particular gun, regardless of weight or BC. If you regularly shoot past that distance, out to 1000 and farther, then you need to stick more to the higher BC bullets, like the Berger Hybrid 140/ELDM 140, and possibly the 147 ELdM whenever it makes it to Canada.
In my Creed, my most accurate 100-300 meter load is 123 Lapua Scenar with Reloder 16, shoots tiny groups, but I shot that load this weekend at 940 yards on steel and it was windy, and my Berger 140 Hybrid load consistently was more on steel and bucked the wind better. Heavier bullet, better BC, less drift.
Working up loads for the Nosler RDF right now but the Berger seemed much easier to find nodes for. Keep in mind though that every rifle likes something different, and it's all trial and range time to tell you what your gun likes best. My 123 Lapua Scenar load really surprised me how good it can group on paper, I wasn't even going to use them in my Creedmoor but was running low on Hybrids so threw a few together and guessed at a recipe, and wow. But shooting the 123s back to back at 940 yards against the 140 Berbers, it was clear the Lapua just wasn't as good in the wind over long distance.