Got to add my voice to the chorus of praise for the 140 grn Nosler Partition--I used it this last season and it was the Angel of Death on everything from coyotes (so accurate I felt confident taking head shots @ stationary ones out to 150 yards), and BIG mule deer. Goes off like a bomb inside the chest, and exits cleanly.
I've had excellent accuracy results with the 129 TSX seated out as far as it'll go, but have yet to shoot anything but paper with this load.
The one bullet I _couldn't_ get my M38 to shoot well was the 160 grain Hornady round tip. The lousy BC doesn't help, but even without the big drop, these suckers were all over the paper.
For powder I like RL 19, and got the best accuracy about midway between my starting and max loads.