I'm hesitating to post this, but here goes. It may not be the most ideal a powder to use for your intended purpose, but that does not mean that it will not/can not work effectively. Just for example, in coming up with reduced loads for a bullet test I'm working on, I used BLC-2 (ball powder slightly slower than 748) in my 270 wsm. It is far from an ideal powder, all the flaws mentioned above would be equally applicable to this cartridge/powder, and any flaws would be further amplified by the larger case volume of the WSM. But low and behold, using some common sense and a reasonable starting load, I got velocities between 2000 and 3000 FPS for most bullets between 100 and 130 Grains. While I was working up a reduced load with 110 Gr Hornady HP's, a 3-shot group was cloverleafed, all touching @ 100.
So, again, it may not be the best choice for your application, but if someone with quickloads runs some pressure estimations and you start low, you might be pleasantly suprised at what you find. Keep it safe, and you have nothing to lose. I would stick to bullets 130 Gr or lower if you do decide to use it, and don't push it for max load, the velocity spread in a fast burning powder and half empty case can vary quite a bit. Here is a breakdown of some of the velocities/charge loads I got using BLC-2, your results with 748 would probably be somewhat similar:
110 Gr Hornady HP, Federal 215M primer, Winchester brass:
43.5 Gr BLC-2: 2644 FPS
44.5 Gr BLC-2: 2668 FPS
45.5 Gr BLC-2: 2759 FPS
46.5 Gr BLC-2: 2880 FPS
47.5 Gr BLC-2: 2934 FPS
48.5 Gr BLC-2: 2963 FPS
Still no pressure signs at this load, I had no reason to go higher though. A fast powder like these will be much better suited in light varmint bullets than any big game-capable bullet.
I only tried 1 load with 130 Gr bullets: Sierra 130 Gr BTSP, Federal 215M, Winchester brass, 33.0 Gr BLC-2: 2135 FPS. I ended up using a slower powder for reduced loads in this weight, so can't comment on how effective it would have been. I don't believe you'll have success with a 150 grain bullet load. Be careful when treading outside the scope of a loading manual (or simply don't do it), and friends with quickloads will save you a lot of time working up from extremely low charges, without worrying about losing appendages. Contrary to what many people believe, loading extremely low charges is not risky, so long as you don't end up with a squib. And it beats starting off too hight. YMMV