"...a 243 but thought I would look for a 22-250 or maybe 223..." Hide damage with any of those depends on the bullet used. Varmint bullets out of them will make big holes in the hide. Commercial FMJ's will not. A commercial fmj is not the same as a milsurp fmj bullet. They have thinner jackets and are made for hide hunting.
I have a 22-250 and found little damage with 40 vmax loaded down (a lot) to about 3450 but found wind drift has been extreme. I have a bunch of Barnes Varmit Grenades loaded up but have yet to try them on a yote. I will let everyone know how they work if I get a chance.
Anyone here have a factory load in 22 250 they were/are impressed with.




























