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It'll work. I've used it for over a decade in my 356Win and 358Win. I'm not sure if I've got the best loads for it worked up though. But such as they are you can see what I've tried here;
One of the best powders for the 45/70, my .300 Whisper, .222Rem., a little fast for most folks, too slow for handguns but too fast for most rifles. The only place I can find it is D. Raynor.