I use the hyper velocity CCI SHP ammo (rated at 1640FPS) out of my 452 Lux as my default ammo for varminting. Call them my little anti-gopher grenades. I get very good accuracy results out of them out past 75 yards, with a nice trajectory - 25 yard zero yields 1/2" high at 50 and 1/4" low at 75.
There are going to be a couple of people who claim the chamber is too tight, but I've put probably 4 or 5 thousand rounds through it (shoot a lot of gophers every year), without any loss of accuracy, and so far, my #### hasn't fallen off.