I use 180 grain Sierra Gamekings with IMR 4350. I cannot complain. Have used it on 4 animals with success, and can get 1/2 inch groups on a good day. I do not remember offhand how many grains of powder, so I won't guess.
The only problem I have is finding brass. When I see it, I buy it. I guess I have about 300 pieces right now, so I am good for awhile