Yes, BC is a moving target... Bore roughness, number of lands and grooves and how that engraves in the bullet, muzzle velocity, twist rate, mag feeding damage can all affect the ACTUAL real world flying through the air BC. Even ambient conditions can have slight affects on this (yes, the programs try to adjust for this in the math IF you can input good info)
best part... as your bore wears and affects the bullets differently, the drop chart will need tweaking (either caused by a change in bullet drag and/or muzzle velocity)
BC is most definitely not a fixed number even from the manf of the bullets... lot to lot variation can and does affect the shape you get in the box... just compare meplat diameters from lot to lot of the same bullet. Berger is one of the best for keeping up with current lot data... and if you track their BCs, they most certainly change them from time to time.. Smart for them and a great service to us shooters.
So I always get a giggle when shooters swear that this bullet must do XYZ and their program will give them accuracy to a 1/4" at 1 million miles. Shoot some bullets and you will quickly see what I mean.
Hell, take the same box of bullets .... load them in a few rifles at similar muzzle velocities and group them on paper at LR.. see what you get.
Being involved in Team shooting with what should be near identical set ups, we always have to tweak what actually happens on target cause things are never perfectly identical. Small adjustments.. sure, but adjustments never the less.
But the solution is very simple.... I print my drop chart and then mark in the corrections I need for my set up. Confirmed over many trips at multiple distances. This was confirmed with my rangefinder, my scope, my ammo, my rifle, my shooting, my real estate. Did I get dead reliable and repeatable drop charts to within 1/4 min out to 1000yds... YEP.
Can you take this data, enter it back into the ballistics software to "tweak" the values so it matches... you can now... and once you do, the software will adjust these tweaks as you go to different locations. So you are creating perfectly "flawed" results that suit you and your set up precisely.
Would it work for another rifle using the same cartridge and bullet.... maybe, but I wouldn't bet a double double on it
Jerry