I've had one for a couple of years, and like it well enough that I recently got a second barrel for it. I was attracted to the easy takedown and return-to-zero QD scope mounting. Both my original barrel (375 H&H) and the newer one (300 Win) are very accurate, sub-MOA with a lot of loads. The gun really does hold zero with repeated disassembly and reassembly.
My gun has the wood stock, even though I had planned to get the synthetic ("professional") model. I will probably eventually get a second one in synthetic, as well as a few more barrels and scope mounts.
The trigger on mine is quite nice for a factory gun; crisp, light and creep-free. I have heard some complaints from a couple of Blaser owners regarding their triggers, but I have no gripes with it. The gun is light and handles well, and the design lends itself to a very short overall length. When I flew with the gun this year, the dismantled rifle, along with two sighted-in scope/mount combos, cleaning gear, binoculars, rangefinder and assorted miscellaneous goodies all fit into a 36-inch Pelican case with room to spare. I could easily have packed the extra barrel in there as well. It's the perfect travellers' rifle.
Mine has only the factory recoil pad which is quite a joke. When I first got the gun I assumed that I would soon be upgrading to a Limbsaver or Decelerator, but I was surprised to find that there was less felt recoil with this gun than any of the other .375's I have owned or shot. I'm satisfied with it as is, but if you are especially recoil-shy, Blaser offers some kind of recoil reducing gizmo that mounts inside the stock.
Negatives: Aside from the high price of the gun, scope mounts, and accessory barrels, I have no major complaints. I would prefer a steel receiver to the aluminum, but I'd hate to think what that would bump the price up to. I would also be happier if Blaser offered a laminated stock set that could replace the walnut on my existing receiver, but they only sell the synthetic model that incorporates the receiver into the stock, and which thus qualifies as a firearm for registration purposes.
In general I am well-pleased with this gun, probably as much as any I have ever purchased. Good luck if you decide to try one out again.