I don't think so, what is the overall length of 45 colt? ,But I don't have these any more to measure. check, Wish I had not sold them all
Useless, but fun, really worked good on mice, but that was when I had lots of cheap 410 stuff kicking around.
At one time you could buy 45colt shot shells, but I would think that would be the same as shooting bird shot in a rifled 22 barrel, waste of time and money. You could ream one barrel to shot shell length, not that I would do that myself.
All the ones in Canada where 4.25 inch that I had, most US ones are 3 in
the 410/45 barrels where 80% chamber, the rifling in them was only about 1 in long, so did not do much of anything, from what I could tell.
But they where made to shoot carjackers in the US at about 2 ft range. Hornaday made special ammo for the purpose. Up here we use a stick or just scream and say thank you.
If you really want to get into this big time, There is a 45/70 one, But I have a limit to overkill at my age .