Wow, I think you are going to get alot of varied reponses to such vague questions!!
But for me, reliability is the MOST important thing in a BP hunting rifle, or any hunting rifle for that matter. With that in mind, you need one that completely seals the primer from external conditions like wind and rain. The Omega and the Encore really seal off the primers so that is one less thing to worry about for me.
As a test, this year I loaded up my Omega on opening morning, and did not unload it until I fired it at a buck five days later. The gun went though everything except snow. It was stored outside at night, and got wet during one particularly intense downfall. The gun fired flawlessly.
I also thin the ability to fire hot magnum loads is an advantage as well. The two guns mentioned above can shoot 150gr of powder, something I would be wary to try in other "magnum" ML'ers.
The only other thing, stay away from Knight's and all their gimmicky systems. I suppose their copy of the Omega, the Revolution is alright, but all of those DISC systems are just one more thing to lose or go wrong. There are already people searching on the exchange forums for places who stock these "discs". How many will be available in 10 or 20 years is anyones guess.
I've handled quite a few ML's over the past few years, and I have to say that for the most part, I have always been impressed with the T/C's. They are built superbly. I wish I could say the same for other brands, but I can't.