The answer to that question is NO.
What kind of a pistol do you think you have that a tiny bit of (maybe) extra pressure is going to blow it up, or make things dangerous?
Are you now loading so high that a couple of pounds extra pressure is dangerous?
Come on, think things out!
Howver, I don't know what company makes bullets that vary by 3%.
The figure of .3% is about right with factory hunting bullets.
Diddling around with "Quickload" I find that Pmax for my particular load, (5.8 gr of N320 under a 185gr JSWC) is 17,595 psi. Switching to a 200 gr bullet and leaving everything else the same gives a Pmax of 21,894 psi which is a difference of 4,299 psi. extrapolating for a bullet weight of 190.55 (+3%) I get a difference of 1,590.63 psi. I do realize that you probably can't just extrapolate like this but the program won't allow for arbitrary changes in bullet weight. Still, a difference of this order combined with other variances such as in COL and tossed loads, its gonna add up, no ? I got the 3% from one of the posts above.
Anyhow, changing parameters by a small margin in "Quickload" yields some surprising results at times and though this time it may not, in fact, be all that significant the difference is still more than a couple of pounds.