I loaded some Small Ginex primers in .45 ACP cases, with CFE Pistol Powder, for a Pard who tried them in his Ruger Blackhawk, using the .45 ACP cylinder.
He had numerous squibs.
He found a great deal of unburned powder in his Ruger.
It was suggested that the Ginex primers are temperature sensitive, which seems to be our experience, as the same primer and powder combo worked fine in warmer weather.
Too confirm this, we have now tried the same loads with ammo kept warm, under our coats and had no squibs.
The loads we left out on the cold loading table produced a number of squibs.
I have also noticed a difference in "hardness" of primers in the same package as well apparent inconsistency in size when seating them, using an RCBS hand primer.