Your efforts to tune a load for your 303 are going to be limited by the optics - in particular if you are shooting iron sights. Since you only have two powders and one bullet, life is easy. Load a few rounds of each powder at min load (max - 4 grains), shoot rifle and compare. You will likely note soot around the neck of the case - this confirms a light load.
If one powder shows substantially better groups, focus on that powder. Make another few rounds with 1 more grain, and a few with 2 more grains. Shoot and compare.
If your first trial shows equal results, then you may chose to do incremental testing with both powders.
For older military rifles like your 303, I would suggest that you avoid going to max published load. Give yourself a couple of grains for margin of safety.
FWIW - Lee Enfields seem to be quite sensitive to bullet weight and configuration. I find the bullet selection to be the principal parameter in achieving accuracy on 303's, moreso than powder type or charge weight... I find the plain ole 150 gr Hornady SP's to be particularly good in many rifles.