The typical "reduced charge powders" are the Hodgdon H4895 , IMR4759 and AA XMP5744
Hodgdons rule of thumb is take any cartridge that lists H4895 as a choice and apply 60% to get the minimum reduced charge . Hodgdon does not claim to need fillers. I have done this lots but the 60% rule still yields relatively high velocities but great results
IMR4759 - limited experience. Good source of reduced load data for this powder is in the Hornady load book and to a lesser degree Speer load book
AA XMP-5744 - This powder is considered the cats meow for reduced loads. Lots of the black powder cartridge shooters use this as a smokeless powder of choice. Picture a 45-70 case with only 20 grains of this powder !
The reason XMP-5744 is the cats ass for reduced / subsonic applications is it was desgined from ground up as a reduced velocity cast bullet powder where it is insensitive to powder positon in the case
I played around with my 458Win Mag ( lots of empty room with this powder ) holding the gun up first to settle the powder to the base and also muzzle down to settle the powder to the front. On average there was no difference in velocity
Only thing with XMP-5744 is there is sometimes unburned powder
Contrary to popular belief reduced loads with these powders is NOT dangerous. The bullet / powder manufactures are ultra careful to cover their ass. The would not publish unsafe load data
Where guys get in trouble are the ones playing around with very fast pistol / shotgun powders like Red Dot in reduced loads with data from unreliable sources
270win reduced load data in the Speer book is a reliable source , as is calling Accurate Arms. Their ballistic gurus will talke your ear off
Only word of caution is lots of the super reduced load data from AA ( 1200 fps etc ) are for cast bullets. If you use this data for jacketed you can stick a bullet in the bore due to lack of pressure
Here is a link to 5744
http://www.accuratearms.com/data/5744.htm
As you can see this powder was designed for use WITHOUT fillers and insensitive to postion. For the guys who are stuffing Dacron etc there are better alternatives nowadays