Pythons have a certain appeal which IMHO is mostly cosmetic, especially in the 2.5 or 4" barrels. The 6" barrels used to be quite accurate and they were perfect for 148 gr. HBWC bullets, but the action stacks as you get near the end of the DA pull. Try to find someone who will do an action job on the Python action can be very difficult if not impossible as most of the good tuners are dead or retired (Ted Telford, Reeves Jungkind, Fred Sakowski).
As NAA said, I think a good S&W is a better gun at almost half the price and lots of people know how to improve a S&W action, but they just get better the more you shoot them!