At 449 flb's with a solid cast lead bullet(I don't recomend round nose, swc or flat point, bigger the better) it would travel the length of the deer. Brodside would be no problem(penatration wise). I shot a few deer under the cronic wasting tag with my .45lc 94 with similarly loaded handloads. On brodside shots it exited every time, even when smashing sholders. If you/they shoot accurately at 100yards I don't see a problem, its not like your going after 350lb mule's, wich would be no problem penatration wise. Be prepaired to track them though with double lung hits, it cuts a clean hole through, with no shredding like a jacked softpoint out of a rifle cartrige. Best is heart/sholders.