For buffalo I would recommend a 458 Win or Lott, 470 NE isn't a bad choice either. They take more killing than an elephant. The 416s are not bad but I would use a bigger bullet myself. I would not use a 375 on buff, if everything is right they will work 100% but if things don't go exactly as planned I would want more horsepower than the 375 delivers. They are unbelievably tough animals, mine took 9 X 400 gn 416s before deciding to expire, all were lethal hits, no fringe hits at all. I was wishing for my 450 Ackley before that fiasco was over, and soft point bullets too. The solids just weren't imparting enough energy and damage on him, I shot the sh!t out of him and he still got up when I walked up to him..............amazing animals, tough as a pigs nose and bullet proof, seriously.