Other than I do not like the 243 Win for larger deer unless it is in an ideal situation and you limit your shot distance the combo you are describing as long as the barrel twist rate is 1 - 9" or 1 - 10" will be able to do the job for you.
Myself I would stay away from the 243 and move up to a 260 Rem or a 257 Roberts and when I feel that I am competent enough that a little more power is in the cards and I had started reloading I would rechamber the 257 to an Ackley Improved.