I have hunted with both my Savage 99 takedown and my Savage 16 stainless, both in .250, and I love them! The .250 is by far my favourite deer cartridge, though I admit that I've had pretty bad luck the last four years. I usually sit in my tree stand with the bolt action, and then I take the lever out for a walk in the woods. As far as loads go, my bolt action prefers the Sierra 117 grain game king over 35 grains of H414, and my lever prefers the super-short Speer 100 grain Hot-cor (or whatever they call them now) over 37 grains of H414. The Speer is the only 100 grain bullet that my 99 will stabilize reliably with its slow twist rate, but with my Marbles tang sight, I can usually get under 2 moa out past 250 metres, which is my comfort zone. So far, I've only gotten a few whitetails with this chambering, but I plan for a coyote or two this winter or spring if I can make it out to the ranches at calving time. I also wouldn't pass over a black bear if I had either of my .250s in my hand....