If you are just starting reloading then there is no discernible difference between the two WRT load development. However, if you want to be completely anal, put a few grains (not more than 1/4 max load) of powder in and fill the mouth of the case with a small wax plug. Fire this and you will have gently fire-formed your brass. Then neck size it and begin your load workup. Make sure that you have a minimum of 100 cases before you start. Load development takes LOTS of rounds and LOTS OF TIME. I usually take a minimum of 50 just to work up a round and a half day at the range. I start at 5% below start load and take it to the max load in stages of .5grn. I load 5 of each charge. I shoot 3-rd groups (the other two are in case of bad fliers) letting the barrel cool between shots.
When I find the one I want, say 45grn is a little open and 45.5 is tight, but 46 opens up again. I will load some at 45.3grn and 45.8 gr. I take a loading set-up to the range with me (all I use is a lee hand press with dies, RCBS digital 750 scale, and a powder trickler at the range in my truck) the cases are already done, the die is already set, just seat the bullet and then crimp the round. Fire for effect. I will then go home, make 100 of that round, go back to zero my rifle. I chrony a minimum of a 10 shot string and shoot a minimum of 50rds to become familiar with the round/rifle combo and still have 50rds left for hunting. RECORD YOUR LOAD SPECIFICS!!
Once I have the load chronied, then I can zero for MPBR. The rest is hard work, hauling the game from the woods.