Which is what, 90% of commercial holsters? The only holsters that may cause issue would be level 2 duty holsters and I'd venture a guess that the majority of folks either don't want, or don't need, a full body, active retention holster. Not to mention, OP is asking specifically for kydex, and I've never come across a kydex cooker that builds a holster that would interfere with the gen 5 ambi safety.
OP, call up Tim from solely Canadian. By far the best holsters made in Canada. Very humble guy who takes pride in his work.
I've been using his stuff since their beginning and it's all quality made stuff.