Glock 22 Gen 4 Sights on a Glok 27 Gen 4?

Not a problem. Just about all Glock parts are interchangeable between Glock models. One exception is the trigger housing in a Gen3 will not work in a Gen 4. Others like the extractor, RSA, and ejector is caliber dependant.
 
Yes.

If you look at any website for aftermarket sights you will see the same part number for that sight on G22 and G27.

There is no difference in Gen 3 and 4 either, as far as sights go.
 
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