IMR4227 is appx 10% faster than IMR4198 and as mentioned is best for cast bullets.
If you're desperate and in a pinch for whatever reason IMR4227 will work in the 303Brit with your 150 grain SP bullets at reasonable velocities, for close range shooting, but IMHO, not acceptable for Deer sized game.
The load I used with a very similar bullet was 32.0 grains of IMR4227, with a Dacron fibre filler, over WLR primers, under 150grn flat base spire point bullets.
Velocities were just over 2300fpx out of a 23 inch No1 MkIII barrel.
I increased the powder charge to 35.0 grains, with a Dacron fibre filler, WLR primers and velocities increased to appx 2500fps.
Both of these loads are on the HOT side, but were SAFE IN MY RIFLE.
This powder is fast and there isn't much room to experiment with. None of the loads I suggested above should be reduced more than 3.0 grains and the Dacron filler needs to be in place to keep the powder charge against the primer flash hole.
Dacron is available at the local fabric shop. It comes in half inch thick, by 3ft wide bolts. A single yard of this fibre will last a lifetime.
I cut it into half inch squares and push it down on top of the powder.
Some folks get their panties in a knot over this practice, claiming it will increase pressures. Maybe, but if you're that close to maximum to worry about it, the load likely is borderline safe anyway.
If you can find a more suitable powder get it. If you can't afford another powder, try to trade what you have for something more suitable.
IMR4227 works best in cases with appx half the capacity of the 303Brit and you can run into some serious issues if you don't hold that powder against the flash hole.
I had much better results with the 125 grain bullets