Have used the Hornady 60gn SP, and the Sierra 63gn projectiles for years in the 222, 223, and 22-250. All were loaded up to use as big game cartridges, tahr, chamois and red deer. They are an excellent projectile for bigger game, so long as you put it in the right place. Sadly we dont have any yotes here in NZ, but we do have wallabies which are thin skinned and about the same size as yotes. They certainly knock them over with authority, and will do some damage if you hit in the very small chest region. Should work well with yotes if you take out the front shoulder.