Ranch Dog (yes the boolit mold guy) has some pretty good info on 45C in the Rossi. His (and mine) preferred load is a 300gr WFN over 24.5gr of Hodgdon Lil'Gun. It's a real little thumper. I use the Lee C452-300-RF as I can no longer find a Ranch Dog mold since he closed up shop. I also have a Lyman 290gr mold made for the 454 Casull that I have cast up a handful from but have yet to try any. Supposed to be very accurate and sized to .452 with a gas check it weighs in at 304gr. It's kind of a truncated cone with a fairly large meplat and should do well for hunting if I find it better for 150yd shots than the Lee which is almost a wadcutter it's meplat is so large lol. While the receiver of the 45 Colt Rossi will handle significantly higher pressure than the above load, the steel crescent butt plate on your shoulder may disagree as will the magazine tube, which will back out under heavy recoil. The tube on the 454 Casull rifles is threaded in and the butt stock is cut flat and has a fairly substantial factory rubber recoil pad. There is also some debate / rumors that the recievers on the 454 Casull models have special heat treating to withstand the +62,000psi Casull pressures.