The 280 is enough gun.
The Fusions, while "bonded" (electrically I think, different process than most bonded bullets) were "designed" for Deer, so the bonding is just tough enough for thin skinned game "by design from Federal" - for that reason alone I wouldn't use them on moose/elk.
I hit a deer last season with a 165 fusion (30.06) at about 25 yards and the bullet "evaporated" - killed the deer fine but there was nothing left of the bullet at all - so much for the bonding process I guess (at least at high velocity impact) - and no, didn't hit any bone, went through the ribs, minced everything in between and left the far side shoulder looking like it was hit with a load of birdshot - so after that experience not only would I not use it on moose or elk, I likewise won't use it for deer anymore either (single experience was enough for me).
When I hunt moose I like a stout bullet but if you aren't hunting with a magnum I do NOT favour mono's (TTSX, GMX etc) which need quite a bit of velocity to mushroom properly - maybe not an issue with deer which are easy to kill, just don't want a pencil hole through a thousand pounds worth of moose.
If you are looking for "off the shelf" Nosler loads 140 accu-bonds for the 280 Rem. And the accu-bond is a "tough" bonded bullet more suitable for moose/elk than the fusion.
Of course, at 200 yards or less a core-lokt is more than you need - you don't have to get fancy unless you are pushing the envelope.