People use them for low power cast bullet loads, the large pistol are around 9 thou shallower in depth and thinner cups.
I would not use them for normal high pressure loads.
This, I've purposely used CCI Magnum Large Pistol primers, to see what would result.
I used a rifle chambered for the 308Win and some Federal cases, which had been fired in the rifle before and had just been reannealed.
I used a start load from the Lyman #49 manual, with Hndy 150grb SP bullets, over 45.0 grains of Win 748.
The result was a reasonably accurate load, with velocities around 2700fps.
The primer was pushed flush with the back of the case and was slightly flattened.
I stepped up the next load to appx halfway between min/max with the same components but 47.0grn of powder.
Velocities were higher, indicating higher pressures at just over 2800fps.
Primers were visibly flattened and starting to crater.
I only loaded one round to maximum, 50.0grn W748, out of curiosity.
The primer was not only cratered/flattend but had leaked hot gasses through the crater and into the bolt. The primer/pocket seal held and there wasn't any blow past.
I didn't check the velocity on the max load.
What I found surprising was that the Magnum Large Pistol primers were giving similar velocities/pressures as their thicker jacket Magnum Large Rifle counterparts.
This test was safe in my rifle, with tight tolerances and brass that had been fire formed to it's chamber.
If I had to use the pistol primers, because I didn't have any of the Magnum Large Rifle primers, I wouldn't be reluctant to do so, as long as the load was kept in the mid range listed in the manual.
I don't do Magnum rifle cartridges and because pressures are usually higher as well as having a longer pressure curve, I would be reluctant to use the Pistol primers, even for the start loads.