I know I'm going to open a can of worms with the "No Cast in Glocks" crowd, but I've had varying results shooting lead in my Glock 21. Everything from major leading to none at all. Just like the other posters above, I seem to get the best results with a slightly oversize (0.001" to 0.002" or so) bullet. I've also found a slightly harder bullet will lead my barrel less, but that may be due to the polygonal rifling in the Glock. The .45 is probably one of the best for handloading cast in, because you shouldn't be able to drive those big slugs fast enough to cause major leading, but some pistols can be finicky. I just do like others here, and wrap some copper "Chore Boy" pot scrubber material around a bore brush and scrub away. The copper stuff is softer than the steel barrel, but much harder than the lead; the fouling should come right out.
Erik.